Research Details

Semaglutide Scientific Research Overview Semaglutide is a long-acting analogue of glucagon-like peptide-1 that acts as a selective GLP-1 receptor agonist. Published research has examined its influence on glucose-dependent insulin signaling, glucagon regulation, appetite-related signaling, energy intake, gastric emptying, body weight, and cardiometabolic outcomes. Published Research Findings In the 68-week STEP 1 trial involving adults with overweight or obesity without diabetes, participants receiving semaglutide experienced an average body-weight reduction of 14.9%, compared with 2.4% with placebo. A substantially larger percentage of semaglutide participants also reached weight-reduction thresholds of 5%, 10%, and 15%. The SELECT cardiovascular-outcomes trial studied adults with overweight or obesity and established cardiovascular disease who did not have diabetes. Semaglutide was associated with an approximately 20% relative reduction in major adverse cardiovascular events compared with placebo. Additional controlled research has reported improvements in several cardiometabolic measurements, although outcomes depend on the population, formulation, study duration, and research protocol. Evidence and Regulatory Context Semaglutide is an active ingredient in FDA-approved prescription products for specific indications. Those approvals apply only to the finished pharmaceutical products reviewed by FDA and do not establish the quality, sterility, safety, or effectiveness of separate research-use semaglutide materials. Research Links STEP 1: Once-Weekly Semaglutide in Adults with Overweight or Obesity SELECT: Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes FDA Wegovy Prescribing Information FDA Information About Unapproved GLP-1 Products Research Context: Published findings summarized on this page involve controlled studies of the named molecule and, where applicable, regulated pharmaceutical formulations. These findings do not establish the identity, purity, sterility, safety, effectiveness, or regulatory status of the research material offered on this page. This product is sold strictly for lawful laboratory research and is not intended for human or veterinary use.